Chronic leukemia myelogenous (CML) is a rare form of bone marrow
cancer—a spongy tissue in the bones that make up blood cells. A larger number
of white blood cells in the blood are caused by CML. The word chronic in chronic
myelogenic leukemia suggests that the development of this cancer is slower than
acute types of leukemia. Chronic myelogenous leukemia may also be called
chronic myelocytic leukemia and chronic granulocyte leukemia. Usually, this
affects elderly people and seldom happens in children, but it can happen at any
age. In this case, the term "myelogenous" refers to the type of cells
affected by this cancer. Advances in the treatment of people with chronic
myelogenic leukemia have led to a substantially improved prognosis. Most people
get remission and survive after diagnosis for several years. Chronic myelogenicleukemia is also not symptomatic. During a blood test, it may be observed.
Generally, there are a few signs and symptoms which occur, some are as follows:
·
Bone pain
·
Bleeding
·
Feeling
full after eating a small amount of food
·
Feeling
run-down or tired
·
Fever
·
Weight
loss without trying
·
Loss of
appetite
·
Pain or
fullness below the ribs on the left side
·
Excessive
sweating during sleep (night sweats)
Chronic myelographic leukemia develops in the bone marrow cells when
there is something terrible about it. What starts with this phase is not clear,
but doctors find out how it progresses towards chronic myelogenic leukemia.
Your blood cells are derived from the bone marrow, which is spongy in your
bones. It creates immature cells (blood stem cells) in a regulated way when
your bone marrow works normally. White blood cells are diseased and develop in
enormous quantities, clump healthy blood cells and damage the bone marrow.
Targeted drug therapy
Specific medicines are designed to attack cancer by concentrating on a particular feature of cancer cells that can enhance and increase cancer. The aim is to obtain the protein from the BCR-ABL gene, tyrosine kinase, in Chronic Myelogenous Leukemia. Initial therapy for diagnosed people with chronicleukemia is a concentrated medicine. Side effects include skin swelling or puffiness, nausea, muscle cramps, tiredness, diarrhea, and skin rashes. To track the efficacy of targeted medication therapy, blood tests are used to detect the existence of BCR-ABL genes. Doctors may recommend other targeted medicines, such as omacetaxine (Synribo), or other treatments if the disease does not respond or resist targeted therapy. Doctors have not identified a safe point where people should avoid taking targeted medicines with chronic myelogenic leukemia. For this reason, even though blood tests remediate the disorder, most people also take targeted medications.
Bone marrow transplant
The only hope of a definite cure for chronic myelogenic leukemia is a
bone marrow transplant, also called a stem cell transplant. High doses of
chemotherapy drugs are used during transplantation of the bone marrow to
destroy the blood-forming cells in the bone marrow. A donor then infuses blood
stem cells into the bloodstream. New cells form new, healthy blood cells to
substitute the diseased cells.
Chemotherapy
Chemotherapy is a drug that destroys rapidly developing body cells,
including leukemia. Chemotherapy medicines are also combined with the treatment
of aggressive chronic myelogenous leukemia. Chemotherapy medications the side
effects of chemotherapy medicines depend on which medications you take.
Medical research
The newest cure for illnesses and innovative approaches to using current
drugs is tested in clinical trials. Registering for chronic myelogenic leukemia
in a clinical trial will give you the ability to pursue the new therapy, but it
cannot guarantee a cure. Discuss what clinical trials are open to you with your
doctor. The advantages and risks of a clinical trial may be addressed jointly.
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