Adrenalcancer is rare cancer that begins in one or both of the small, triangular glands (adrenal glands) on the top of your kidneys. Adrenal glands produce hormones that give direction to virtually every organ and tissue in your body. Adrenal cancer, also known as adrenocortical cancer, can occur at any age. But it is most likely to affect children younger than 5 years of age and adults in the 40s and 50s.
The inner
part of the adrenal gland, the medulla, is an extension of the nervous system.
Nervous system hormones such as norepinephrine and epinephrine (also called
adrenaline) are produced in the medulla. Tumours and cancers that begin in the
adrenal medulla include pheochromocytomas (most often benign) and
neuroblastomas. Tumours and adrenal cortex cancers are covered here, but there
are no adrenal medulla tumours. Neuroblastomas are treated separately
elsewhere.
Healing
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The two main types of adrenal cortex tumours are:
Adenomas
(benign or non-cancer tumours)
Carcinomas
(cancer or malignant tumours)
Treatment:
Adenomas can be cured by removing the adenoma-containing adrenal gland. Some
adrenal adenomas that cause hormone-related symptoms may be effectively treated
with drugs that block the production or action of these hormones. This may be
the best treatment option for patients with other serious medical problems who
may not be able to have major surgery.
The type of
cancer in the adrenal glands cortex is called adrenal carcinoma or simply
adrenal cancer. The majority of cancers found in the adrenal gland are not
sugar cancers. This rare type of cancer is also known as adrenocortical cancer
(or carcinoma). Instead, they began to spread through the bloodstream to the
accede glands in other bodies or tissues. Lung, melanoma, and breast cancers,
for example, frequently spread into the adrenal. When others spread to the
adrenals, adrenal cancer is not considered. They are named and treated based on
where they started.
Testing procedures used to identify adrenal
cancer
Blood and urine tests. Laboratory blood and urine tests may reveal unusual levels of hormones
produced by the adrenal glands, including cortisol, aldosterone, and androgens.
Testing the imagery. Your doctor may recommend CT, MRI, or positron emission tomography
(PET) scans to better understand any growths in your adrenal glands and to see
if cancer has spread to other parts of your body, such as your lungs or your
liver.
Analysis of your adrenal gland in the laboratory. If your doctor suspects that you may have adrenal cancer, he or she
may recommend that you remove the affected adrenal gland. The gland is analysed
in a laboratory by a doctor who studies the tissues of the body (pathologist).
Treatment
of adrenal cancer usually involves surgery to remove all cancers. Other
treatments may be used to prevent cancer from returning or if surgery is not an
option.
Surgery: The goal of
surgery is to remove all of adrenal cancer. To achieve this, all affected
adrenal gland (adrenalectomy) must be removed by the physician.
Drugs to reduce the risk of recurrence: An older drug Mitotane may be recommended after surgery to treat
advanced adrenal cancer has shown promise to delay the recurrence of the disease
after surgery.
Radiotherapy: High-energy
beams, like X-rays and protons, are used by radiation therapy to kill cancer
cells.
Physiotherapy: Chemotherapy
is a drug that uses chemicals to kill cancer cells. Chemotherapy may be an
option to slow the progression of cancer in the case of adrenal cancers that cannot
be removed by surgery or returned after initial treatment.
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